Open AccessNanosponges: A Novel Class of Drug Delivery System - Review
Author(s) -
Subramanian Selvamuthukumar,
Anandam Singireddy,
K. Krishnamoorthy,
R. Manavalan
Publication year - 2012
Publication title -
journal of pharmacy and pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.497
H-Index - 78
ISSN - 1482-1826
DOI - 10.18433/j3k308
Subject(s) - drug , drug delivery , nanotechnology , solubility , chemistry , biochemical engineering , pharmacology , materials science , biology , engineering , organic chemistry
ABSTRACT - Effective targeted drug delivery systems have been a dream for a long time, but it has been largely frustrated by the complex chemistry that is involved in the development of new systems. The invention of nanosponges has become a significant step toward overcoming these problems. Nanosponges are tiny sponges with a size of about a virus, which can be filled with a wide variety of drugs. These tiny sponges can circulate around the body until they encounter the specific target site and stick on the surface and begin to release the drug in a controlled and predictable manner. Because the drug can be released at the specific target site instead of circulating throughout the body it will be more effective for a particular given dosage. Another important character of these sponges is their aqueous solubility; this allows the use of these systems effectively for drugs with poor solubility.
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