Open AccessPreparation and Evaluation of a New Nano Pharmaceutical Excipients and drug Delivery System Based in Polyvinylpyrrolidone and Silicates
Author(s) -
Camila Braga Dornelas,
Alex Moura da Silva,
Cide Brizio Dantas,
Carlos Rangel Rodrigues,
Sandra Solange Coutinho,
P.C Sathler,
Helena Carla Castro,
Luiza R.S. Dias,
Valéria Pereira de Sousa,
Lúcio Mendes Cabral
Publication year - 2011
Publication title -
journal of pharmacy and pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.497
H-Index - 78
ISSN - 1482-1826
DOI - 10.18433/j3hc72
Subject(s) - polyvinylpyrrolidone , nanocomposite , intercalation (chemistry) , montmorillonite , dissolution , materials science , ammonium bromide , chemical engineering , dissolution testing , nuclear chemistry , chemistry , polymer chemistry , organic chemistry , composite material , pulmonary surfactant , biopharmaceutics classification system , engineering
PURPOSE: This work describes the preparation of new nanocomposites based on lamellar silicates (AAM-alkyl ammonium montmorillonite) obtained by the intercalation of PVP K30 and glyceril monostearate.
METHODS: By XRD, TGA and DSC analysis the AAM was characterized and its compactation characteristics, functionality and toxicity were also tested. The AAM/PVP K-30 and AAM/GME nanocomposite obtained were evaluated to identify the interlamellar spacing values by XRD diffratograms. Tablets were prepared using methyldopa and theophylline as model drugs and the dissolution tests were carried out in simulated gastric fluid and simulated enteric fluid.
RESULTS: AAM showed a good compactability and compressibility characteristics for tablets preparation. The intercalation yields (approximately 25%) of the nanocomposites were efficient. The AAM/PVP K-30 nanocomposites were successfully tested as dissolution enhancers and sustained release matrixes.
CONCLUSIONS: The results also suggested the promising use of AAM (viscogel B8) and the new nanocomposite prepared by clay/PVP K-30 intercalation as a new matrix for sustained release and the feasibility of using these new nanocomposites as dissolution enhancer.