Open AccessRegional Differences in the Components of Luminal Water from Rat Gastrointestinal Tract and Comparison with Other Species.
Author(s) -
Yusuke Tanaka,
Tadayuki Hara,
Ryoichi Waki,
Shunji Nagata
Publication year - 2012
Publication title -
journal of pharmacy and pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.497
H-Index - 78
ISSN - 1482-1826
DOI - 10.18433/j3f602
Subject(s) - jejunum , gastrointestinal tract , phospholipid , absorption (acoustics) , griseofulvin , chemistry , small intestine , solubility , medicine , biochemistry , pathology , membrane , physics , acoustics , organic chemistry
The bile acids, phospholipids, inorganic ions, and pH in luminal fluid are very important factors for the dissolution and oral absorption of solid drugs. In this study, we evaluated the regional differences in these factors in the rat GI tract. The solubility of griseofulvin, a poorly water-soluble drug, in the luminal fluid in each segment was also measured. In addition, the data from rats were compared with those from other species published previously to evaluate the species differences in the composition of luminal fluid.