In vitro Treatment with cis-[Ru(H-dcbpy-)2(Cl)(NO)] Improves the Endothelial Function in Aortic Rings with Endothelial Dysfunction | Zendy

Jorge Oishi | Zendy; Tereza Cristina Buzinnari | Zendy; Cezar Rangel Pestana | Zendy; Thiago Francisco de Moraes | Zendy; Izabela Pereira Vatanabe | Zendy; David A. Wink | Zendy; Roberto Santana da Silva | Zendy; Lusiane Maria Bendhack | Zendy; Gerson Jhonatan Rodrigues | Zendy

Open Access

In vitro Treatment with cis-[Ru(H-dcbpy-)2(Cl)(NO)] Improves the Endothelial Function in Aortic Rings with Endothelial Dysfunction

Author(s) -

Jorge Oishi,

Tereza Cristina Buzinnari,

Cezar Rangel Pestana,

Thiago Francisco de Moraes,

Izabela Pereira Vatanabe,

David A. Wink,

Roberto Santana da Silva,

Lusiane Maria Bendhack,

Gerson Jhonatan Rodrigues

Publication year - 2015

Publication title -

journal of pharmacy and pharmaceutical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.497

H-Index - 78

ISSN - 1482-1826

DOI - 10.18433/j3cc9k

Subject(s) - endothelium , acetylcholine , endothelial dysfunction , potency , nitric oxide , chemistry , incubation , superoxide dismutase , in vitro , medicine , biochemistry , endocrinology , pharmacology , oxidative stress

The ruthenium complex cis-[Ru(H-dcbpy-)2(Cl)(NO)] (DCBPY) is a nitric oxide (NO) donor and studies suggested that the ruthenium compounds can inactivate O2-. The aim of this study is to test if DCBPY can revert and/or prevent the endothelial dysfunction.

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