Open AccessIn vitro Treatment with cis-[Ru(H-dcbpy-)2(Cl)(NO)] Improves the Endothelial Function in Aortic Rings with Endothelial Dysfunction
Author(s) -
Jorge Oishi,
Tereza Cristina Buzinnari,
Cezar Rangel Pestana,
Thiago Francisco de Moraes,
Izabela Pereira Vatanabe,
David A. Wink,
Roberto Santana da Silva,
Lusiane Maria Bendhack,
Gerson Jhonatan Rodrigues
Publication year - 2015
Publication title -
journal of pharmacy and pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.497
H-Index - 78
ISSN - 1482-1826
DOI - 10.18433/j3cc9k
Subject(s) - endothelium , acetylcholine , endothelial dysfunction , potency , nitric oxide , chemistry , incubation , superoxide dismutase , in vitro , medicine , biochemistry , endocrinology , pharmacology , oxidative stress
The ruthenium complex cis-[Ru(H-dcbpy-)2(Cl)(NO)] (DCBPY) is a nitric oxide (NO) donor and studies suggested that the ruthenium compounds can inactivate O2-. The aim of this study is to test if DCBPY can revert and/or prevent the endothelial dysfunction.