Open AccessАлгоритмическое и информационное обеспечение разработки готовых лекарственных форм (ГЛФ) лекарственных средств в твердой форме
Author(s) -
В Ф Корнюшко,
О. М. Николаева,
Р Р Биглов,
К.Ю. Колыбанов,
О.А. Филоретова
Publication year - 2021
Publication title -
тенденции развития науки и образования
Language(s) - English
DOI - 10.18411/lj-02-2021-08
Subject(s) - computer science , process (computing) , block (permutation group theory) , quality (philosophy) , development (topology) , software , mathematical optimization , mathematics , mathematical analysis , philosophy , geometry , epistemology , programming language , operating system
The article discusses the problem of creating an algorithmic and informational support for the pharmaceutical development of ready-made medicines (GLF) medicines in solid form. For the system implementation of the algorithms for the development of GLF on the basis of the principle of QbD (quality-by-design - quality planned during development) it is proposed to apply the methodology of system design based on the principle (diagrams) of Demming. The algorithms for modeling and optimizing the selection of the technology platform for the pharmaceutical development of GLF medicines in solid form are given. The block scheme of the developed algorithm of the simulation and optimization process based on multi-tissue regression models and the online algorithm of optimization of Huka-Jeeves is presented. Testing of the developed algorithmic and software on the example of the development of the drug diphenhydramine.