Open AccessUtilization of direct forcing immersed boundary methods for the optimization of inertial focusing microfluidics
Author(s) -
Patrick Giolando,
Hui Ma,
Tamara L. KinzerUrsem,
Steve Wereley
Publication year - 2021
Publication title -
international symposium on particle image velocimetry.
Language(s) - English
Resource type - Journals
ISSN - 2769-7576
DOI - 10.18409/ispiv.v1i1.49
Subject(s) - microfluidics , lift (data mining) , mechanics , inertial frame of reference , fictitious force , materials science , physics , nanotechnology , classical mechanics , computer science , data mining
Inertial focusing microfluidics have gained significant momentum in the last decade for their ability to separate and filter mixtures of particles and cells based on size [1-3]. However, the most important feature is that the separation is passive, without the need for external forces. At the heart of inertial focusing is the balance between counteracting lift forces: shear and wallinduced lift. Shear-induced lift is a product of the curvature of the fluid flow and the rotation of the particle in the flow, while wall-induced lift is generated by the disturbance of the fluid by the particle near a wall. This phenomenon was first observed by Segre and Silberberg for the focusing of particles in a pipe, and was later extended to the focusing of cells and particle in rectangular channels [4]. Taking advantage of inertial focusing we explore particle capture utilizing an expanded channel microfluidics chip design. By expanding a small region of the straight channel microvortices form in the well, which allows for size selective trapping of particles.