Circ_FOXO3 regulates KLF6 through sponge adsorption of miR-122-5p to repress H2O2-induced HBVSMC proliferation, thus promoting IA development in vitro model | Zendy

Pei Dong Yue | Zendy; Ya Nan Lu | Zendy; Lei Zhang | Zendy; Fei Zheng | Zendy

Open Access

Circ_FOXO3 regulates KLF6 through sponge adsorption of miR-122-5p to repress H2O2-induced HBVSMC proliferation, thus promoting IA development in vitro model

Author(s) -

Pei Dong Yue,

Ya Nan Lu,

Lei Zhang,

Fei Zheng

Publication year - 2022

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2020_6021

Subject(s) - foxo3 , in vitro , microrna , apoptosis , transfection , cancer research , chemistry , biology , gene , protein kinase b , genetics

The phenotypic transformation of human brain vascular smooth muscle cells (HBVSMC) is widely involved in the appearance and progression of intracranial aneurysms (IA). Aneurysm (IA) Circular RNA circ_FOXO3 functions pivotally in vascular diseases and tumors, but its regulatory role as well as its molecular mechanism in IA is still uncertain. This research was to explore how circ_FOXO3 works and its mechanism in vitro model of HBVSMC IA induced by H2O2.

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