Open AccessUnexplored potential: Biologically active compounds produced by microorganisms from hard-to-reach environments and their applications
Author(s) -
Zuzanna Cyske,
Weronika Jaroszewicz,
Magdalena Żabińska,
Patryk Lorenc,
Maja Sochocka,
Patrycja Bielańska,
Łukasz Grabowski,
Lidia Gaffke,
Karolina Pierzynowska,
Grzegorz Węgrzyn
Publication year - 2021
Publication title -
acta biochimica polonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.452
H-Index - 78
eISSN - 1734-154X
pISSN - 0001-527X
DOI - 10.18388/abp.2020_5887
Subject(s) - antifungal , microorganism , drug discovery , antimicrobial , antibiotic resistance , biology , bacteria , chemistry , antibiotics , computational biology , microbiology and biotechnology , bioinformatics , genetics
Rapid development of antibiotic resistance of bacteria and fungi, as well as cancer drug resistance, has become a global medical problem. Therefore, alternative methods of treatment are considered. Studies of recent years have focused on finding new biologically active compounds that may be effective against drug-resistant cells. High biodiversity of hard-to-reach environments offers sources to search for novel molecules potentially applicable for medical purposes. In this review article, we summarize and discuss compounds produced by microorganisms from hot springs, glaciers, caves, underground lakes, marine ecosystems, and hydrothermal vents. Antibacterial, antiviral, antifungal, anticancer, anti-inflammatory, and antioxidant potential of these molecules are presented and discussed. We conclude that using compounds derived from microorganisms occurring in extreme environments might be considered in further studies on development of treatment procedures for diseases caused by drug-resistant cells.