Isoxanthanol has protective and anti-inflammatory effects on subchondral bone deterioration in experimental osteoarthritic rat model | Zendy

Xin Li | Zendy; Jie Yu | Zendy; Yan Zhao | Zendy; Yating Bai | Zendy; Lixin Fu | Zendy; Zilong Ma | Zendy; Shuqin Zhang | Zendy

Open Access

Isoxanthanol has protective and anti-inflammatory effects on subchondral bone deterioration in experimental osteoarthritic rat model

Author(s) -

Xin Li,

Jie Yu,

Yan Zhao,

Yating Bai,

Lixin Fu,

Zilong Ma,

Shuqin Zhang

Publication year - 2022

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2020_5634

Subject(s) - osteoarthritis , in vivo , subchondral bone , medicine , interleukin , pharmacology , inflammation , chemistry , endocrinology , pathology , cytokine , articular cartilage , biology , alternative medicine , microbiology and biotechnology

In the present study isoxanthanol was investigated for treatment of monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in vivo. The study demonstrated that isoxanthanol inhibited excessive release of interleukin-6, NO and PGE2 in RAW264.7 cells treated with LPS in dose dependent manner. The effects of isoxanthanol were examined in a rat model of osteoarthritis (OA) and observed to ameliorate inflammatory damage and protect against OA. Moreover, in vivo data also confirmed inhibition of interleukin-6, NO and PGE2 levels in LPS-induced OA-rats. Deterioration of knee subchondral bone in LPS-induced OA-rats was also prevented effectively by isoxanthanol-treatment. Therefore, isoxanthanol prevents subchondral bone deterioration in OA rats via targeting inflammatory processes.

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