Open AccessA biomimetic approach to some specifically functionalized cyclic terpenoids.
Author(s) -
Veaceslav Kulciţki
Publication year - 2007
Publication title -
acta biochimica polonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.452
H-Index - 78
eISSN - 1734-154X
pISSN - 0001-527X
DOI - 10.18388/abp.2007_3132
Subject(s) - terpenoid , chemistry , cascade , ring (chemistry) , stereochemistry , surface modification , substrate (aquarium) , closure (psychology) , sequence (biology) , combinatorial chemistry , organic chemistry , biology , biochemistry , ecology , chromatography , economics , market economy
The paper relates on the current advancements in the synthesis of complex cyclic terpenoids by superacidic induced cyclization of open chain precursors. It is shown that functional groups disposal in the initial substrate strongly influences the reaction outcome. Possible variations of the investigated compound structures include particularly alpha-functionalization and alpha,omega-bifunctionalization. This approach allowed a selective initiation of cyclization sequence from an internal double bond or suspending the ring closure cascade to partially cyclized compounds. The reported synthetic schemes are attempts to mimic the biogenetical processes postulated in the living systems.