Open AccessThe structure of the Ca2+-ATPase of sarcoplasmic reticulum.
Author(s) -
Anthony Martonosi,
Sławomir Pikuła
Publication year - 2003
Publication title -
acta biochimica polonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.452
H-Index - 78
eISSN - 1734-154X
pISSN - 0001-527X
DOI - 10.18388/abp.2003_3690
Subject(s) - endoplasmic reticulum , serca , atpase , lamellar structure , sarcoplasm , chemistry , biophysics , calcium atpase , crystallography , biochemistry , biology , enzyme
In this article the morphology of sarcoplasmic reticulum, classification of Ca(2+)-ATPase (SERCA) isoenzymes presented in this membrane system, as well as their topology will be reviewed. The focus is on the structure and interactions of Ca(2+)-ATPase determined by electron and X-ray crystallography, lamellar X-ray and neutron diffraction analysis of the profile structure of Ca(2+)-ATPase in sarcoplasmic reticulum multilayers. In addition, targeting of the Ca(2+)-ATPase to the sarcoplasmic reticulum is discussed.