Open AccessLipids and signal transduction in the nucleus.
Author(s) -
Anna Dygas,
Jolanta Barańska
Publication year - 2001
Publication title -
acta biochimica polonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.452
H-Index - 78
eISSN - 1734-154X
pISSN - 0001-527X
DOI - 10.18388/abp.2001_3937
Subject(s) - signal transduction , nucleus , transduction (biophysics) , microbiology and biotechnology , phospholipase c , function (biology) , cell nucleus , phosphoinositide phospholipase c , biology , nuclear localization sequence , phospholipase , inositol , chemistry , biochemistry , enzyme , receptor
During the last few years a growing amount of data has accumulated showing phospholipid participation in nuclear signal transduction. Very recent data strongly support the hypothesis that signal transduction in the nucleus is autonomic. Local production of inositol polyphosphates, beginning with the activation of phospholipase C is required for their specific function in the nucleus. Enzymes which modify polyphosphoinositols may control gene expression. Much less information is available about the role of other lipids in nuclear signal transduction. The aim of this minireview is to stress what is currently known about nuclear lipids with respect to nuclear signal transduction.