Open AccessThe left-handed double helical nucleic acids.
Author(s) -
Billyde Brown,
Alexander Rich
Publication year - 2001
Publication title -
acta biochimica polonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.452
H-Index - 78
eISSN - 1734-154X
pISSN - 0001-527X
DOI - 10.18388/abp.2001_3916
Subject(s) - nucleic acid , rna , nucleotide , left handed , chemistry , rna editing , rna silencing , adenosine deaminase , double stranded , enzyme , biochemistry , biophysics , stereochemistry , dna , biology , physics , gene , rna interference , optics
The conversion of right-handed dsDNA and dsRNA to the left-handed Z-conformation involves a reorganization of the nucleotides relative to each other. This conversion can be facilitated by the tight binding of a Z-conformation-specific protein domain from the editing enzyme dsRNA adenosine deaminase. This may influence the modification of both pre-mRNAs as well as some replicating RNA viruses.