The left-handed double helical nucleic acids. | Zendy

Betty A. Brown | Zendy; Alexander Rich | Zendy

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The left-handed double helical nucleic acids.

Author(s) -

Betty A. Brown,

Alexander Rich

Publication year - 2001

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2001_3916

Subject(s) - nucleic acid , rna , nucleotide , left handed , chemistry , rna editing , rna silencing , adenosine deaminase , double stranded , enzyme , biochemistry , biophysics , stereochemistry , dna , biology , physics , gene , rna interference , optics

The conversion of right-handed dsDNA and dsRNA to the left-handed Z-conformation involves a reorganization of the nucleotides relative to each other. This conversion can be facilitated by the tight binding of a Z-conformation-specific protein domain from the editing enzyme dsRNA adenosine deaminase. This may influence the modification of both pre-mRNAs as well as some replicating RNA viruses.

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