Open Access4-Hydroxy-2,3-nonenal as a signal for cell function and differentiation.
Author(s) -
Mario U. Dianzani,
Giuseppina Barrera,
Maurizio Parola
Publication year - 1999
Publication title -
acta biochimica polonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.452
H-Index - 78
eISSN - 1734-154X
pISSN - 0001-527X
DOI - 10.18388/abp.1999_4184
Subject(s) - lipid peroxidation , oxidative stress , chemotaxis , function (biology) , oxidative phosphorylation , chemistry , signal transduction , biochemistry , polyunsaturated fatty acid , cell growth , cell , microbiology and biotechnology , cell signaling , biology , receptor , fatty acid
4-Hydroxy-2,3-nonenal (HNE) is a biologically active aldehydic end product of oxidative decomposition of omega-3 and omega-6 polyunsaturated fatty acids of membrane phospholipids, a process referred to as lipid peroxidation. HNE has been detected in several experimental and clinical conditions in which oxidative stress has been reported to occur and several authors have suggested that HNE and related 4-hydroxy-2,3-alkenals (HAKs) of different chain length may act not only as toxic and mutagenic mediators of oxidative stress-related injury but also as biological signals in normal and pathological conditions. In this paper we will review the literature supporting the concept that HNE and HAKs may act as signal molecules able to modulate biological events such as chemotaxis, signal transduction, gene expression, cell proliferation and cell differentiation.