Open AccessFluorescence decay time distribution analysis of cyclic enkephalin analogues. Influence of the solvents and configuration of amino acids in position 2 and 3 on changes in conformation.
Author(s) -
Joanna Malicka,
Małgorzata Groth,
Cezary Czaplewski,
Adam Liwo,
Wiesław Wiczk
Publication year - 1999
Publication title -
acta biochimica polonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.452
H-Index - 78
eISSN - 1734-154X
pISSN - 0001-527X
DOI - 10.18388/abp.1999_4134
Subject(s) - chemistry , fluorescence , solvent , acceptor , amino acid , amino acid residue , population , peptide , stereochemistry , distribution (mathematics) , crystallography , peptide sequence , organic chemistry , biochemistry , physics , demography , quantum mechanics , sociology , gene , condensed matter physics , mathematical analysis , mathematics
The lifetime distribution calculations were applied to study the influence of configuration of amino-acid residues in positions 2 and 3 on changes in conformation of the peptide chain of cyclic analogues of enkephalins containing a fluorescence energy donor and acceptor in different solvents. In all the solvents studied the lifetime distributions were bimodal. This testified to the presence of two families of conformations. In this paper the relationship between the population of each conformation and configuration of the residues in position 2 and 3, and the solvent used is discussed.