Open AccessTranslational frameshift sites within bacteriophage lambda genes rexA and cI.
Author(s) -
Sidney Hayes,
Harold J. Bull
Publication year - 1999
Publication title -
acta biochimica polonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.452
H-Index - 78
eISSN - 1734-154X
pISSN - 0001-527X
DOI - 10.18388/abp.1999_4109
Subject(s) - frameshift mutation , operon , repressor , bacteriophage , lambda , genetics , mechanism (biology) , lambda phage , polarity (international relations) , gene , biology , physics , mutation , escherichia coli , gene expression , quantum mechanics , cell
Phage lambda's cI-rexA-rexB operon displays an intriguing example of regulation by an unexplained mechanism of polarity. We have identified three potential -1 translational frameshift sites and present a model for translational frameshift suppression by lambda's CI repressor as a mechanism of regulating operon polarity, implying an additional role for CI self-regulation.