Some aspects of oligoribonucleotides synthesis via the H-phosphonate approach. | Zendy

Jacek Stawiński | Zendy; Adam Kraszewski | Zendy

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Some aspects of oligoribonucleotides synthesis via the H-phosphonate approach.

Author(s) -

Jacek Stawiński,

Adam Kraszewski

Publication year - 1998

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.1998_4349

Subject(s) - phosphonate , ribonucleoside , chemistry , combinatorial chemistry , stereoselectivity , stereochemistry , biochemistry , rna , catalysis , gene

This review gives a short account of selected aspects of oligoribonucleotide synthesis via the H-phosphonate method. It includes: (i) recent methods for the preparation of suitably protected ribonucleoside 3'-H-phosphonates (the phosphonylation step), (ii) some chemical and stereochemical features of the formation of H-phosphonate internucleosidic linkages, and (iii) stereoselective synthesis of oligoribonucleoside phosphorothioates using chemo-enzymatic approach.

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