Open AccessSome aspects of oligoribonucleotides synthesis via the H-phosphonate approach.
Author(s) -
Jacek Stawiński,
Adam Kraszewski
Publication year - 1998
Publication title -
acta biochimica polonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.452
H-Index - 78
eISSN - 1734-154X
pISSN - 0001-527X
DOI - 10.18388/abp.1998_4349
Subject(s) - phosphonate , ribonucleoside , chemistry , combinatorial chemistry , stereoselectivity , stereochemistry , biochemistry , rna , catalysis , gene
This review gives a short account of selected aspects of oligoribonucleotide synthesis via the H-phosphonate method. It includes: (i) recent methods for the preparation of suitably protected ribonucleoside 3'-H-phosphonates (the phosphonylation step), (ii) some chemical and stereochemical features of the formation of H-phosphonate internucleosidic linkages, and (iii) stereoselective synthesis of oligoribonucleoside phosphorothioates using chemo-enzymatic approach.