High molecular mass dextran sulfate increases expression of HIV-1 coreceptor CCR-5 in macrophage-monocytes in culture. | Zendy

Paweł P. Jagodzińśki | Zendy; W H Trzeciak | Zendy

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High molecular mass dextran sulfate increases expression of HIV-1 coreceptor CCR-5 in macrophage-monocytes in culture.

Author(s) -

Paweł P. Jagodzińśki,

W H Trzeciak

Publication year - 1998

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.1998_4306

Subject(s) - monocyte , infectivity , macrophage , chemistry , molecular mass , human immunodeficiency virus (hiv) , dextran , biology , immunology , virus , biochemistry , in vitro , enzyme

It has been reported that high molecular mass dextran sulfate (HMDS) enhances the infection of monocyte-macrophages by HIV-1. We observed that in monocyte-macrophages maintained in the presence of HMDS the expression of HIV-1 coreceptor CCR-5 was increased approximately 5-fold at the transcriptional level. We postulate that the increased expression of CCR-5 might be responsible for HMDS-enhanced infectivity of monocyte-macrophages by HIV-1.

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