Open AccessDNA repair of adriamycin induced damage in mouse and human cells differing in catalase activity.
Author(s) -
Beata Gruber,
Elżbieta Anuszewska
Publication year - 1998
Publication title -
acta biochimica polonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.452
H-Index - 78
eISSN - 1734-154X
pISSN - 0001-527X
DOI - 10.18388/abp.1998_4249
Subject(s) - catalase , dna damage , cytotoxic t cell , dna repair , chemistry , dna , microbiology and biotechnology , enzyme , biochemistry , biology , in vitro
Catalase is known to counteract cytotoxic effect of adriamycin, used as an anti-neoplastic drug. In cells with low catalase activity no repair of adriamycin induced lesions was observed up to 48 h post treatment. In cells with high catalase activity after 48 h the repair was either complete or partial depending on the human or mouse cell type used.