Open AccessActivity of liver proteases in experimental methanol intoxication.
Author(s) -
Elżbieta Skrzydlewska,
Z Skrzydlewski,
K Worowski
Publication year - 1997
Publication title -
acta biochimica polonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.452
H-Index - 78
eISSN - 1734-154X
pISSN - 0001-527X
DOI - 10.18388/abp.1997_4430
Subject(s) - cathepsin , proteases , chemistry , body weight , cathepsin b , cathepsin d , methanol , biochemistry , endocrinology , enzyme , biology , organic chemistry
Intoxication of rats with methanol (1.5 and 3.0 g/kg body weight) led to a significant, time- and dose-dependent decrease in the activities of cathepsins A, B and C, while the activity of cathepsin D was unaffected. The decrease was associated with a different partial release of individual cathepsins to the post-lysosomal fraction.