Open AccessPsoralen photosensitization: damages to nucleic acid and membrane lipid components.
Author(s) -
Sergio Caffieri,
Z Zarebska,
Francesco Dall’Acqua
Publication year - 1996
Publication title -
acta biochimica polonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.452
H-Index - 78
eISSN - 1734-154X
pISSN - 0001-527X
DOI - 10.18388/abp.1996_4557
Subject(s) - photobiology , nucleic acid , phototoxicity , psoralen , chemistry , dna , rna , biochemistry , biology , botany , gene , in vitro
For decades the therapeutic properties of psoralens were related to their photochemical reactions with DNA and RNA. Such approach, although fruitful in treatments, did not explain satisfactorily the way of healing of the multitude of diseases manifested through skin disorders. The new research field presented in our review is directed to another target: the lipid components of the cell. The studies on the photobiology of phospholipids may help to elucidate the phototoxic and pigment inducing activity of psoralens.