New insights regarding the potential of the pronucleotide approach in antiviral chemotherapy. | Zendy

G. Gosselin | Zendy; JeanLuc Girardet | Zendy; Christian Périgaud | Zendy; S. Benzaria | Zendy; Isabelle Lefèbvre | Zendy; Nathalie Schlienger | Zendy; Alain Pompon | Zendy; J.L. IMBACH | Zendy

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New insights regarding the potential of the pronucleotide approach in antiviral chemotherapy.

Author(s) -

G. Gosselin,

JeanLuc Girardet,

Christian Périgaud,

S. Benzaria,

Isabelle Lefèbvre,

Nathalie Schlienger,

Alain Pompon,

J.L. IMBACH

Publication year - 1996

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.1996_4553

Subject(s) - chemistry , in vivo , enzyme , biochemistry , stereochemistry , combinatorial chemistry , pharmacology , computational biology , biology , microbiology and biotechnology

The rationale for a pronucleotide approach based on the use of phosphotriesters which incorporate enzyme-mediated bio-labile protection is discussed in detail. Among the studied bio-labile phosphate protecting groups, the S-acyl-2-thioethyl (SATE) groups appeared the most promising as exemplified in cell culture systems in the case of the pronucleotides of 3'-azido-3'-deoxythymidine, 2',3'-didehydro-3'-deoxythymidine, 2',3'-dideoxyadenosine and acyclovir In vivo implementations of such bis(SATE) pronucleotides have been planned for future animal studies.

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