Recent progress in oligonucleotide synthesis. | Zendy

Wolfgang Pfleiderer | Zendy; S. Matysiak | Zendy; Frank Bergmann | Zendy; Rainer Schnell | Zendy

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Recent progress in oligonucleotide synthesis.

Author(s) -

Wolfgang Pfleiderer,

S. Matysiak,

Frank Bergmann,

Rainer Schnell

Publication year - 1996

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.1996_4515

Subject(s) - acetal , intramolecular force , oligonucleotide , oligomer , combinatorial chemistry , chemistry , protecting group , elongation , cleavage (geology) , function (biology) , catalysis , stereochemistry , organic chemistry , materials science , biochemistry , biology , dna , alkyl , evolutionary biology , fracture (geology) , metallurgy , composite material , ultimate tensile strength

New blocking group combinations for the machine-aided oligoribonucleotide synthesis on solid phase material have been developed and tested regarding their general application. An acetal function for 2'-OH protection offers a series of advantages in the synthetic approach but special conditions have to be fulfilled in order to guarantee a selective cleavage of the temporary 5'-OH blocking group such as the dansylethoxycarbonyl or even the acid-labile dimethoxytrityl group in the chain elongation process. The final removal of the 2'-O-acetal function in the partially deblocked oligomer proceeds unexpectedly well under weak acidic conditions due to a supposed intramolecular acid catalysis.

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