Open AccessAza and diaza bioisosteric anthracene-9,10-diones as antitumor agents.
Author(s) -
A. Paul Krapcho,
Martin J. Maresch,
Miles P. Hacker,
Ernesto Menta,
Ambrogio Oliva,
F Giuliani,
Silvano Spinelli
Publication year - 1995
Publication title -
acta biochimica polonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.452
H-Index - 78
eISSN - 1734-154X
pISSN - 0001-527X
DOI - 10.18388/abp.1995_4896
Subject(s) - anthracene , nitrogen atom , mitoxantrone , chemistry , stereochemistry , combinatorial chemistry , chemotype , organic chemistry , biology , genetics , chemotherapy , chromatography , group (periodic table) , essential oil
Synthetic routes to aza and diaza bioisosteres related to the anthracene-9,10-dione, mitoxantrone, have been developed. The antitumor properties of these chemotypes are compared with those exhibited by the corresponding carbocyclic analogues. The sensitivity of the expressed cytotoxicities on the position(s) of the nitrogen atom(s) are discussed in terms of potential cellular targets. Several analogues show potential for clinical evaluations.