Cis-DDP induced alteration of DNA structure studied by scanning tunneling microscopy. | Zendy

Tomasz H. Zastawny | Zendy; W. Olejniczak | Zendy; Ryszard Ólinski | Zendy

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Cis-DDP induced alteration of DNA structure studied by scanning tunneling microscopy.

Author(s) -

Tomasz H. Zastawny,

W. Olejniczak,

Ryszard Ólinski

Publication year - 1993

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.1993_4798

Subject(s) - scanning tunneling microscope , dna , chemistry , crystallography , helix (gastropod) , microscopy , quantum tunnelling , biophysics , nanotechnology , materials science , biology , biochemistry , optics , physics , optoelectronics , ecology , snail

Scanning tunneling microscopy (STM) was used to study the structural changes of DNA induced by the antitumor drug cis-diamminedichloroplatinum. The STM image showed a dramatic structural perturbation of the DNA by complexed Pt with the characteristic bend of the double helix.

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