Open AccessCis-DDP induced alteration of DNA structure studied by scanning tunneling microscopy.
Author(s) -
Tomasz H. Zastawny,
W. Olejniczak,
Ryszard Oliński
Publication year - 1993
Publication title -
acta biochimica polonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.452
H-Index - 78
eISSN - 1734-154X
pISSN - 0001-527X
DOI - 10.18388/abp.1993_4798
Subject(s) - scanning tunneling microscope , dna , chemistry , crystallography , helix (gastropod) , microscopy , quantum tunnelling , biophysics , nanotechnology , materials science , biology , biochemistry , optics , physics , optoelectronics , ecology , snail
Scanning tunneling microscopy (STM) was used to study the structural changes of DNA induced by the antitumor drug cis-diamminedichloroplatinum. The STM image showed a dramatic structural perturbation of the DNA by complexed Pt with the characteristic bend of the double helix.