Open AccessNa+,K(+)-ATPase activity of rabbit kidney cortex membranes in ischemia and reperfusion.
Author(s) -
Selvin Aydin,
Aysel Arıcıoğlu,
Nurten Türközkan,
Fuat Bingol,
C. Aydın
Publication year - 1993
Publication title -
acta biochimica polonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.452
H-Index - 78
eISSN - 1734-154X
pISSN - 0001-527X
DOI - 10.18388/abp.1993_4796
Subject(s) - lipid peroxidation , microsome , chemistry , ischemia , kidney , atpase , enzyme , medicine , oxygen , endocrinology , cortex (anatomy) , renal cortex , biochemistry , biology , organic chemistry , neuroscience
The activity of Na+,K(+)-ATPase in the microsomal fraction of rabbit kidney cortex was strongly decreased by ischemia and increased slightly, but not significantly, after reperfusion. These changes were correlated with a dramatic increase in lipid peroxidation in microsomes isolated from both ischemic and reperfused kidneys. This correlation may point to irreversible impairment of the enzymatic function under the influence of either oxygen free radicals or lipid peroxidation.