Z-RNA. The synthesis of 2'-O-[13C]methyl- and 5-methyl-analogs of ribo-CGCGCG. | Zendy

Ewa Biała | Zendy; Jan Milecki | Zendy; A. KOWALEWSKI | Zendy; Mariusz Popenda | Zendy; W. Z. ANTKOWIAK | Zendy; Ryszard W. Adamiak | Zendy

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Z-RNA. The synthesis of 2'-O-[13C]methyl- and 5-methyl-analogs of ribo-CGCGCG.

Author(s) -

Ewa Biała,

Jan Milecki,

A. KOWALEWSKI,

Mariusz Popenda,

W. Z. ANTKOWIAK,

Ryszard W. Adamiak

Publication year - 1993

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.1993_4793

Subject(s) - phosphoramidite , guanosine , silylation , chemistry , reagent , derivative (finance) , rna , stereochemistry , carbon 13 nmr , organic chemistry , oligonucleotide , catalysis , biochemistry , dna , financial economics , economics , gene

Chemical synthesis of 2'-O-[13C]methyl-rCGCGCG and 5-methyl-rCGCGCG using support-aided phosphoramidite method is presented. 2'-O-Methyl guanosine derivative was separated from its 3'-O-methyl counterpart using transient 5',3'-O-silylation with 1,3-dichloro-1,1,3,3-tetraisopropyldisiloxane (Markiewicz reagent). The hexamers were obtained in a purity suitable for NMR studies.

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