Open AccessSynthetic Derivatives of Natural Alkaloid Harmine
Author(s) -
N. M. Ismagulova,
Ж. С. Нурмаганбетов,
А. Ж. Турмухамбетов,
Т. С. Сейтембетов,
С. М. Адекенов
Publication year - 2016
Publication title -
eurasian chemico-technological journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.227
H-Index - 9
eISSN - 2522-4867
pISSN - 1562-3920
DOI - 10.18321/ectj281
Subject(s) - harmine , peganum harmala , alkaloid , chemistry , phthalic anhydride , indole alkaloid , tryptamine , organic chemistry , ammonium , botany , biology , biochemistry , neuroscience , catalysis
The indole alkaloid harmine was extracted from underground part of Peganum harmala L. With the purpose of obtaining the new biological active derivatives on base of alkaloid harmine the chemical modification was carried out. The p-toluolsulfochlorid, p-toluolsulfoacid, hydrochloric, sulfuric, nitric acids, dioxide selenium and phthalic anhydride have been chosen as modifiers. For the first time quaternary ammonium salts, derivatives of N-oxide and N (2)-oxyharminiumphthalate harmine are synthesized. The structure of the synthesized compounds is determined by methods of the spectral analysis and X-ray analysis. Antimicrobic and phagocytosis stimulating activities of isolated alkaloids and their derivatives are investigated.