Open AccessAbnormal Glucose Metabolism in Nonalcoholic Fatty Liver Disease
Author(s) -
Meng Li,
Li Zhang,
Guang Ji
Publication year - 2018
Publication title -
integrative gastroenterology and hepatology
Language(s) - English
Resource type - Journals
ISSN - 2637-6954
DOI - 10.18314/igh.v1i1.1210
Subject(s) - nonalcoholic fatty liver disease , insulin resistance , hypertriglyceridemia , metabolic syndrome , medicine , endocrinology , fatty liver , type 2 diabetes , carbohydrate metabolism , diabetes mellitus , lipid metabolism , disease , bioinformatics , biology , triglyceride , cholesterol
Nonalcoholic Fatty Liver Disease (NAFLD), a common cause of chronic liver disease, represents a spectrum of histopathologic abnormalities. NAFLD is often associated to the typical components of the metabolic syndrome (MS), with characteristics including abdominal obesity, type 2 diabetes, Insulin Resistance (IR), hypertension, and Hypertriglyceridemia, and has seriously threatened human health. IR, a crucial element of MS, is the fundamental contributor in the process of NAFLD. Therapy strategies are finite and, for now, are basically concentrated on weight reduction and utilization of insulin sensitizing agents. Recent literature indicated IR related to the abnormal glucose metabolism play a pivotal role in the development of NAFLD. Moreover, glucose resistance, glucocorticoid hormones, leptin, et al are also associated with glucose metabolism dysfunction in NAFLD. We highlight the mechanisms of these components in NAFLD, and our work might be beneficial for comprehending the mechanism and treatment of abnormal glucose metabolism in patients with NAFLD.