Open AccessOvarian tissue cryopreservation from contemporary indications to cutting edge research
Author(s) -
Limor Man,
Zev Rosenwaks,
Daylon James
Publication year - 2018
Publication title -
current opinion in gynecology and obstetrics
Language(s) - English
Resource type - Journals
ISSN - 2637-4617
DOI - 10.18314/cogo.v1i1.1100
Subject(s) - infertility , ovarian tissue cryopreservation , ovarian tissue , medicine , fertility preservation , premature ovarian failure , malignancy , radiation therapy , intensive care medicine , gynecology , surgery , ovary , fertility , pregnancy , biology , population , genetics , environmental health
Over the last three decades, survival rate from malignancies has steadily increased, turning major focus on quality of life in remission. Unfortunately, a major side effect of medical interventions including chemotherapy, radiotherapy, and/or surgery is premature ovarian failure and infertility for many patients. Ovarian tissue cryopreservation is an experimental technique used to preserve reproductive potential in patients who are pre-pubertal, must urgently undergo gonadotoxic treatment or who have other medical conditions requiring treatment that may undermine ovarian reserve and will lead to sub or infertility. We will review the indications, available techniques of tissue harvesting, and methods for freezing and autotransplanting cortical ovarian tissue. We will discuss outcomes, the potential risk of reintroducing malignancy and lastly, cutting-edge research models being developed in the field.