Open AccessEvaluating the Anti-Cancer Efficacy of Ethanolic Extract of Erythrina variegate Linn. – An In-silico Approach
Author(s) -
G Umarani,
S. Nethaji
Publication year - 2021
Publication title -
journal of natural remedies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.154
H-Index - 19
eISSN - 2320-3358
pISSN - 0972-5547
DOI - 10.18311/jnr/2021/26223
Subject(s) - colorectal cancer , kras , oncogene , suppressor , in silico , medicine , cancer , cancer research , traditional medicine , oncology , pharmacology , biology , gene , genetics , cell cycle
Colorectal cancer is one of the deadly diseases and is ranked as third for men and second for women amongst all cancers in the world. Due to 6,08,000 deaths, it ranks as the fourth common cause of death due to cancer (WHO, 2018). The “ethnomedicinal studies” of the therapeutic values of plants evolves a systematic scientific evaluation. In the present study, the lead compounds hit on the GCMS analysis of the ethanolic extract of Erythrina variegata L. Leaf. The extract was studied for its anticancer potential in Insilco molecular docking. The results revealed that the 3-eicosyne have strong binding energies against the colorectal cancer mutated oncogene KRAS G12D and tumour suppressor gene p53 R249S in comparison to other compounds. Finally, it is confirmed that the active pharmaceutical ingredients have potent anti-Cancer activity and have great efficacy against the colorectal adenocarcinoma oncogenes and tumour suppressor regulating genes.