Preliminary Analysis of the Antidiabetic Activity of Indonesian Polyherbal Formulation | Zendy

Syamsudin Abdillah | Zendy; Apriala Gita Lestari | Zendy; Priskila Monika | Zendy; Wahono Sumaryono | Zendy; Kartiningsih Hisyam | Zendy

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Preliminary Analysis of the Antidiabetic Activity of Indonesian Polyherbal Formulation

Author(s) -

Syamsudin Abdillah,

Apriala Gita Lestari,

Priskila Monika,

Wahono Sumaryono,

Kartiningsih Hisyam

Publication year - 2021

Publication title -

journal of natural remedies

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.154

H-Index - 19

eISSN - 2320-3358

pISSN - 0972-5547

DOI - 10.18311/jnr/2021/25960

Subject(s) - acarbose , traditional medicine , alloxan , alpha glucosidase , positive control , stevia rebaudiana , medicine , diabetes mellitus , ethanol , ic50 , pharmacology , chemistry , in vitro , food science , biochemistry , endocrinology , enzyme

This study aims to prepare polyherbal formulations and also analyze the antidiabetic potentials of the prepared polyherbal in animals. The ethanol extracts of the leaves of Smallanthus sonchifolius , Stevia rebaudiana, Syzygium polyanthum , and Camellia sinensis were used in this study. The extracts of the aforementioned plants were prepared in the ratio of 2:1:1:1. The formulation was tested for antidiabetic activity in vitro through the inhibition of alpha-glucosidase and in vivo using alloxan-induced diabetes in mice. The polyherbal has an inhibitory effect with the IC 50 value of 26.23 μg/mL compared to acarbose (control) was 17.02 μg/mL. The diabetic animals were observed to show an obvious decline in glucose level when compared with control (P< 0.001) after treatment.

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