Open AccessPreliminary Analysis of the Antidiabetic Activity of Indonesian Polyherbal Formulation
Author(s) -
Syamsudin Abdillah,
Apriala Gita Lestari,
Priskila Monika,
Wahono Sumaryono,
Kartiningsih Hisyam
Publication year - 2021
Publication title -
journal of natural remedies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.154
H-Index - 19
eISSN - 2320-3358
pISSN - 0972-5547
DOI - 10.18311/jnr/2021/25960
Subject(s) - acarbose , traditional medicine , alloxan , alpha glucosidase , positive control , stevia rebaudiana , medicine , diabetes mellitus , ethanol , ic50 , pharmacology , chemistry , in vitro , food science , biochemistry , endocrinology , enzyme
This study aims to prepare polyherbal formulations and also analyze the antidiabetic potentials of the prepared polyherbal in animals. The ethanol extracts of the leaves of Smallanthus sonchifolius , Stevia rebaudiana, Syzygium polyanthum , and Camellia sinensis were used in this study. The extracts of the aforementioned plants were prepared in the ratio of 2:1:1:1. The formulation was tested for antidiabetic activity in vitro through the inhibition of alpha-glucosidase and in vivo using alloxan-induced diabetes in mice. The polyherbal has an inhibitory effect with the IC 50 value of 26.23 μg/mL compared to acarbose (control) was 17.02 μg/mL. The diabetic animals were observed to show an obvious decline in glucose level when compared with control (P< 0.001) after treatment.