Open AccessIn Vitro Anti-cancer, Anti-hypertensive and Antihyperglycaemic effect of Hypoxis colchicifolia
Author(s) -
Suggessan Moodley,
Depika Dwarka,
Himansu Baijnath,
John J. Mellem
Publication year - 2021
Publication title -
journal of natural remedies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.154
H-Index - 19
eISSN - 2320-3358
pISSN - 0972-5547
DOI - 10.18311/jnr/2021/25315
Subject(s) - traditional medicine , pharmacology , in vivo , camptothecin , corm , in vitro , medicine , captopril , medicinal plants , chemistry , biochemistry , botany , biology , microbiology and biotechnology , blood pressure
Economic challenges associated with non-communicable diseases and the sociocultural outlook of many patients especially in Africa has increased the dependence on traditional herbal medicines for these diseases. Hypoxis colchicifolia is a traditional medicinal plant used in Southern Africa against an array of ailments. This study evaluated the in vitro antidiabetic (α-amyalse and α-glucosidase), antihypertensive (angiotensin-converting enzyme) and anticancer potential of H. colchicifolia corm as well as leaf (acetone, methanol and aqueous) extracts. Results showed that extracts have a moderate anti-diabetic and anti-hypertensive potential, with great anti-cancer potential. The acetone extract of both fresh and dried corms produced significant α-amylase and α-glucosidase inhibition with ACE inhibited predominantly by the dried corms methanolic extract (IC 50 368.2 μg/mL). Methanolic extract of dried leaves showed the least cytotoxicity against the noncancerous cell line HEK-293 while exhibiting the highest inhibition of MCF-7 cells (IC 50 3.24 μg/mL). All extracts exhibited a greater inhibitory potential in A549 cells than the positive control camptothecin (IC 50 304.2μg/mL). This study reveals that H. colchicifolia has therapeutic potential as an anti-diabetic and anticancer agent; however, further in vivo studies need to be conducted.