Open AccessIn vitro Antibacterial Activity of <i>Manilkara hexandra</i> (Sapotaceae) Seed Extracts and Violacein against Multidrug Resistant <i>Streptococcus mutans
Author(s) -
Krishna Kumar Patel,
Arwa Kaizer Ali,
N. Divakaran Nair,
Vijay Kothari
Publication year - 2015
Publication title -
journal of natural remedies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.154
H-Index - 19
eISSN - 2320-3358
pISSN - 0972-5547
DOI - 10.18311/jnr/2015/466
Subject(s) - streptococcus mutans , minimum bactericidal concentration , minimum inhibitory concentration , antibacterial activity , chemistry , traditional medicine , ic50 , microbiology and biotechnology , biology , antimicrobial , food science , in vitro , bacteria , biochemistry , medicine , genetics
Extracts of the Pongamia pinnata, Manilkara hexandra, and Pyrus pyrifolia seeds prepared by microwave assisted extraction method, and the violet pigment- violacein extracted from Chromobacterium violaceoum were screened for their antibacterial activity against Streptococcus mutans.M. hexandra extracts were able to inhibit both the test strains of S. mutans used in this study with minimum inhibitory concentration (MIC) ranging from 600-800 µg/mL. These extracts exerted bactericidal action against S. mutans with minimum bactericidal concentration (MBC) of 600-900 µg/mL. Acetone extract of M. hexandra seeds registered highest average total activity of 231.20 mL/g. Extraction efficiency was found to have a moderately good correlation with antibacterial activity. Violacein exerted bactericidal action with MIC and MBC of less than 2 µg/mL against both the strains.