Open AccessInteraction between Bone Cells in Bone Remodelling
Author(s) -
M. Ashwin Chandra Veni,
P. Rajathi
Publication year - 2017
Publication title -
journal of academy of dental education
Language(s) - English
Resource type - Journals
eISSN - 2348-2621
pISSN - 2348-1595
DOI - 10.18311/jade/0/15952
Subject(s) - osteoclast , bone remodeling period , bone resorption , bone remodeling , osteoblast , bone cell , microbiology and biotechnology , chemistry , paracrine signalling , secretion , bone formation , endocrinology , biology , biochemistry , in vitro , receptor
Bone forms the basic framework of the body and it consists of bone cells, ground substance and collagen fibres. The bone undergoes alternate deposition and resorption to withstand the biomechanical forces exerted. Osteoclasts, osteoblasts, osteocytes secrete numerous enzymes, cytokines, growth factors which interact among one another to perform the physiological activities taking place in bone. This article emphasizes on the secretions of osteoblast that interacts with the osteoclast precursor involved in osteoclastic stimulation and inhibition and vice versa osteoclastic activity on bone can trigger osteoblastic formation or inhibition. This interaction is explained based on 3 different modes: Direct cell-cell contact, gap junctions, diffusion of paracrine factors and the 3 phases of bone remodelling.