Open AccessImmunofluorescence in Oral Dermatological Disorders- No Shiny Matter
Author(s) -
Umamaheswari Kanniah,
Unnimaya Varghese,
V. S. Sruthi,
Mathew Jacob
Publication year - 2017
Publication title -
journal of academy of dental education
Language(s) - English
Resource type - Journals
eISSN - 2348-2621
pISSN - 2348-1595
DOI - 10.18311/jade/0/15951
Subject(s) - immunofluorescence , medicine , pathology , direct fluorescent antibody , dermatology , dermatological diseases , antibody , immunochemistry , skin biopsy , disease , biopsy , immunology
Dermatological diseases with underlying immunological pathosis exhibiting similar clinical manifestations have challenged even the veteran dermatologists in rendering diagnosis clinically, necessitating study of the skin lesions with immunofluroscence. The technique is similar to immunochemistry where instead of enzymes antibodies are labelled with a fluorescent dye4. It probes the study of the cell and molecular biology. Immunofluorescence permit early diagnosis, treatment and subsequent monitoring of disease activity in patient with potentially life threatening disease. It is widely used in the field of vesiculo-bullous lesions and other related oral dermatological disorders by demonstrating antibodies either in biopsy tissue or in the serum separated from blood collected from the patients.