Open AccessHypercalcaemia: A portent of sarcoidosis in cystic fibrosis
Author(s) -
B Jayakrishnan,
Saif Al-Mubaihsi,
Masoud Kashoub,
Jojy George
Publication year - 2019
Publication title -
sultan qaboos university medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.258
H-Index - 27
eISSN - 2075-0528
pISSN - 2075-051X
DOI - 10.18295/squmj.2018.18.04.018
Subject(s) - medicine , hypercalcaemia , sarcoidosis , hepatosplenomegaly , cystic fibrosis , pathology , prednisolone , dermatology , mediastinal lymphadenopathy , radiology , gastroenterology , disease , biopsy , calcium
The coexistence of cystic fibrosis (CF) and sarcoidosis is rare. We report a 22-year-old male cystic fibrosis patient who presented multiple times to the Sultan Qaboos University Hospital, Muscat, Oman, in 2013. He was diagnosed with non-parathyroid-related hypercalcaemia and anterior uveitis, while computed tomography revealed mediastinal and abdominal lymphadenopathy and mild hepatosplenomegaly. These findings, in addition to the presence of calciuria and a high angiotensin-converting enzyme (ACE) level, confirmed a clinical diagnosis of sarcoidosis. The patient responded well to treatment with oral prednisolone which, over the course of two years, resulted in the near-complete resolution of parenchymal nodular infiltrates, regression of hilar lymphadenopathy, resolution of hypercalcaemia and the normalisation of his ACE levels. Diagnosing pulmonary sarcoidosis in CF can be challenging as most adult patients already have extensive lung disease. Physicians should be aware that hypercalcaemia may be an early manifestation of sarcoidosis in such cases.Keywords: Sarcoidosis; Cystic Fibrosis; Hypercalcemia; Case Report; Oman.