Open AccessStudy of the derivatives of 1-adamantane carboxylic acid to induced plateletaggregation human in vitro
Author(s) -
Alfiya S Gilmutdinova,
В. А. Ермохин,
Н. А. Кленова,
Pyotr P. Purygin
Publication year - 2015
Publication title -
vestnik samarskogo universiteta. estestvennonaučnaâ seriâ
Language(s) - English
Resource type - Journals
eISSN - 2712-8954
pISSN - 2541-7525
DOI - 10.18287/2541-7525-2015-21-10-143-150
Subject(s) - hemoglobin , in vitro , chemistry , trypsin , cytosol , adamantane , peptide , biochemistry , biophysics , biology , enzyme , organic chemistry
The study of condition of the system of hemoglobin, release of peptide com- pounds, and proteolytic activity of human erythrocytes under conditions of hy- perglycemia of varying degrees is carried out. The increase in the level of hy- perglycemia is accompanied by a decrease of anity of hemoglobin to oxygen and the growth of level of metgemoglobin, the glycosylated hemoglobin level is increased in conditions of severe hyperglycemia. The level of formation of pep- tides in erythrocytes and the level of output of their cells is determined by the increase in trypsin-like activity in cytosol and increased membrane permeability of red blood cells.