Open AccessCOMPARATIVE ANALYSIS OF RESPIRATORY REACTIONS TO MICROINJECTION OF GABA AND PENICILLIN INTO THE BOTZINGER COMPLEX AND THE PRE-BOTZINGER COMPLEX IN RATS
Author(s) -
Н.Г. Маньшина,
O. A. Vedyasova
Publication year - 2012
Publication title -
vestnik samarskogo universiteta. estestvennonaučnaâ seriâ
Language(s) - English
Resource type - Journals
eISSN - 2712-8954
pISSN - 2541-7525
DOI - 10.18287/2541-7525-2012-18-3.1-210-218
Subject(s) - microinjection , gabaa receptor , penicillin , respiratory system , inhibitory postsynaptic potential , gaba receptor antagonist , respiratory center , antagonist , tidal volume , receptor , anesthesia , pharmacology , neuroscience , chemistry , bicuculline , medicine , biology , biochemistry , antibiotics
In acute experiments on anesthetized rats, the respiratory responses to local administration of GABA (10^{-5}М) and noncompetitive GABAA antagonist penicillin (10^{-7} М) into B¨otzinger complex (BC) and pre-B¨otzinger complex (PBC) were studied. The dierences in the responses of respiratory frequency, inspiratory and expiratory duration after injection of GABA into the BC and PBC were found. The eects were more pronounced when GABA administered into the PBC. It is shown that the response of tidal volume, in contrast, was more frequent when both GABA and penicillin injected into the BC. The question of the role of GABA receptors of BC and PBC in the realization of the inhibitory action of GABA on the temporal and volumetric parameters of breathing pattern is discussed.