Open AccessCircular RNA (circRNA) and YAP in tumor: A review
Author(s) -
Li Xu,
Xiaodong Tian,
Xin Mu,
Zhenzhen Liang,
Xiaohui Xu,
Haiyun Yu
Publication year - 2019
Publication title -
general surgery
Language(s) - English
Resource type - Journals
ISSN - 2529-7732
DOI - 10.18282/gs.v3i1.851
Subject(s) - circular rna , hippo signaling pathway , carcinogenesis , effector , rna , biology , cell growth , gene , microbiology and biotechnology , gene expression , cancer research , genetics
Background: Circular Ribonucleic Acid (circRNA) is a type of RNA that has been found in recent years and is a closed loop structure widely found in eukaryotic cells. Present situation: The circRNA is stable in nature, highly conserved and tissue and disease specific, and regulates target gene expression at the transcriptional or posttranscriptional level, which is related to the occurrence and development of tumors. YAP (Yes-associated protein) is the main effector of Hippo signaling pathway. It is found that YAP level is closely related to cell proliferation and apoptosis, tissue organ size control and tumorigenesis. Aim: to study the correlation between circRNA and YAP in tumors.