Open AccessRare CBFB-MYH11 cryptic rearrangement in acute myeloid leukemia with ins(16)(p13.1q22q22)
Author(s) -
Hailing Zhang,
Elizabeth M. Sagatys,
Haipeng Shao,
Kenian Liu
Publication year - 2017
Publication title -
advances in modern oncology research
Language(s) - English
Resource type - Journals
eISSN - 2424-7855
pISSN - 2424-7847
DOI - 10.18282/amor.v3.i1.165
Subject(s) - fusion gene , myeloid leukemia , biology , cancer research , fluorescence in situ hybridization , chimeric gene , gene , chromosomal translocation , microbiology and biotechnology , genetics , gene expression , chromosome
Acute myeloid leukemia (AML) with CBFB-MYH11 fusion gene is almost always associated with either inv(16)(p13.1q22) or t(16;16)(p13.1;q22). Only a few variants leading to formation of this chimeric gene have been reported. In this report, we describe a novel type of CBFB-MYH11 fusion variant generated by an insertion of CBFB into the MYH11 gene, which is identifiable by fluorescence in situ hybridization (FISH).