Open AccessFrequency cumulative effect of subthreshold energy laser-activated remote phosphors irradiation on visual function in guinea pigs
Author(s) -
Yufei Zhang,
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Ruidan Cao,
Jun-Bo Song,
Dongyu Wei,
FuJun Duan,
Wei Wang,
Zuoming Zhang,
Tao Chen,
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Publication year - 2022
Publication title -
international journal of ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.634
H-Index - 29
eISSN - 2227-4898
pISSN - 2222-3959
DOI - 10.18240/ijo.2022.02.04
Subject(s) - erg , rhodopsin , calretinin , irradiation , retina , medicine , guinea pig , laser , ophthalmology , retinal , optics , physics , endocrinology , immunohistochemistry , nuclear physics
AIM: To explore the effects of laser-activated remote phosphors (LARP) on visual function in guinea pigs.METHODS: Electroretinogram (ERG) of guinea pigs were observed after LARP irradiation at different frequencies and irradiation times. We evaluated the expression of rhodopsin, β-catenin, connexin36, calretinin, and calbindin in the retina of guinea pigs and measured the density of photoreceptor cells after high-frequency LARP irradiation.RESULTS: After LARP irradiation, the ERG results showed that the amplitude of the dark-adapted 3.0 b-wave of the model eye was lower than that of the control eye after high-frequency irradiation (P<0.05). The expression of rhodopsin, β-catenin, connexin36, calretinin, and calbindin in the retina of guinea pig declined.CONCLUSION: There is frequency cumulative damage effect on the retina that relates to LARP illumination frequency. This has significance for staff visual protection policies under LARP lighting conditions.