Open AccessInhibition of LY294002 in retinal neovascularization via down-regulation the PI3K/AKT-VEGF pathway in vivo and in vitro
Author(s) -
Yu Di,
Xiaolong Chen
Publication year - 2018
Publication title -
international journal of ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.634
H-Index - 29
eISSN - 2227-4898
pISSN - 2222-3959
DOI - 10.18240/ijo.2018.08.06
Subject(s) - pi3k/akt/mtor pathway , protein kinase b , ly294002 , medicine , vascular endothelial growth factor , neovascularization , angiogenesis , andrology , biology , signal transduction , microbiology and biotechnology , vegf receptors
To investigate the effects of the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 on retinal neovascularization (RNV) in the oxygen-induced retinopathy (OIR) mouse model and human umbilical vein endothelial cells (HUVECs).