Open AccessDuctal papilloma with atypical ductal hyperplasia – Understanding the importance of immunohistochemistry- A case report
Author(s) -
Nisarga Rani R,
Anjali Rao,
Siddhartha Sankar Biswas,
K Madan
Publication year - 2022
Publication title -
ip journal of diagnostic pathology and oncology/ip journal of diagnostic pathology and oncology/journal of diagnostic pathology and oncology
Language(s) - English
Resource type - Journals
eISSN - 2581-3706
pISSN - 2456-6284
DOI - 10.18231/j.jdpo.2022.013
Subject(s) - intraductal papilloma , papilloma , malignancy , ductal carcinoma , medicine , pathology , hyperplasia , immunohistochemistry , breast cancer , carcinoma , cancer
Solitary intraductal papilloma of the breast is a common benign mammary proliferative disease and is the most common neoplasm associated with nipple discharge in women. Women with solitary papillomas have 1.5-2.0 times increased risk of developing invasive carcinoma. The papillary lesions of the breast include a broad spectrum of disorders from benign papilloma, atypical papilloma to papillary carcinoma. Benign papilloma on core needle biopsy has been found to have concurrent malignancy in about 3–5% of cases at excision. Solid papillomas commonly pose a diagnostic dilemma due to similarities with other ominous papillary lesions. The presence of ADH within a papilloma and/or in the surrounding breast is associated with an increased risk of recurrence or invasive carcinoma. The present study undertakes to fully describe the morphological changes occurring within the epithelial component of central papillomas and to search for factors of prognostic significance concerning recurrence, progression and differentiation of atypical ductal hyperplasia.