Open AccessT-Lymphoblastic lymphoma presenting with obstructive jaundice and pleural effusion; role of flow cytometry on pleural fluid: A case report
Author(s) -
Namrata P Awasthi,
S Anshima
Publication year - 2021
Publication title -
ip journal of diagnostic pathology and oncology/ip journal of diagnostic pathology and oncology/journal of diagnostic pathology and oncology
Language(s) - English
Resource type - Journals
eISSN - 2581-3706
pISSN - 2456-6284
DOI - 10.18231/j.jdpo.2021.051
Subject(s) - medicine , pleural effusion , differential diagnosis , lymphoma , pathology , lymphoblastic lymphoma , medical diagnosis , jaundice , radiology , gastroenterology , immunology , t cell , immune system
T-cell lymphoblastic lymphoma often presents as a large mediastinal mass in the anterior mediastinum with shortness of breath as chief complaint. We, put forward a case of T-LBL, presenting with obstructive jaundice and, later developing pleural effusion. Diagnosis was clinched by Flow Cytometry (FCM) performed on the pleural fluid, which revealed, neoplastic lymphoid cells; suggesting T-cell Lymphoproliferative disorder. Bone marrow examination and immunohistochemistry revealed CD3+, TDT+, CD10+, CD34- and CD20- blasts. Thus, diagnosis of T-ALL/LBL was rendered. Clinicians should be mindful that TALL/LBL can uniquely present with obstructive jaundice, proffering serious diagnostic dilemma. FCM should be attempted on any available body fluids/effusions, in appropriate clinical settings, as it can contribute substantially, in making a rapid diagnosis and, initiating early therapy. 1. Leukemia/lymphoma should be considered in the differential diagnoses, when the initial work-up for obstructive jaundice, is inconclusive; 2. FCM can be performed on any fluid/effusion sample for hematolymphoid neoplasm and can aid in making a rapid diagnosis.