Clinicopathological study of epithelial neoplasms of ovary with special reference to the expression of P53 and Her2/neu in epithelial carcinoma

Ovarian cancer represents 30% of all cancers of female genital tract. An accurate histopathological diagnosis of ovarian tumours is essential for their management and the outcome of therapy. Clinicopathological study of ovarian epithelial neoplasms and to study the expression of p53 and Her2/neu in epithelial carcinoma of ovary and their association with the histological grade. An observational descriptive type of study in a tertiary care hospital in Eastern India. 72 cases diagnosed as ovarian epithelial neoplasms in the department of Pathology, CNMC&H Kolkata during the study period of January, 2019 to December, 2020 were studied. Specimens were processed routinely. Immunohistochemistry was done following standard protocol. Statistical analysis was done using SPSS (version 21.0, Chicago inc., Chicago, Illinois, USA) software. 57 cases were benign followed by 14 malignant and 1 borderline case. Majority of the tumours were serous type (71.4%) followed by mucinous (27.2%) and seromucinous (1.4%). P53 expression was noted in 50% of the epithelial ovarian carcinoma and 85.7% of the high grade serous carcinoma. Her2/neu expression was noted in 21.4% of epithelial ovarian carcinoma cases. p53 expression was more in serous carcinoma and the expression of p53 was associated with higher grade of serous carcinoma. Her2/neu expression was more in serous carcinoma. There was no significant association between Her2/neu expression and histological grade and a larger population based study is needed for further evaluation.