Open AccessMalignant mixed germ cell tumours- A rare case report with unusual presentation in a 05 years old female child
Author(s) -
Ritu Sonkar,
Himanshu Kumar,
Pooja Nagayach,
Puneet Srivastava
Publication year - 2021
Publication title -
indian journal of pathology and oncology
Language(s) - English
Resource type - Journals
eISSN - 2394-6792
pISSN - 2394-6784
DOI - 10.18231/j.ijpo.2021.084
Subject(s) - immature teratoma , dysgerminoma , endodermal sinus tumor , medicine , yolk sac , choriocarcinoma , pathology , struma ovarii , ovary , seminoma , germ cell , germ cell tumors , biology , surgery , chemotherapy , embryo , biochemistry , gene , microbiology and biotechnology
Mixed germ cell tumours (MGCT) of the ovary are malignant neoplasms of the ovary comprising of two or more types of germ cell components. Most of the malignant MGCT consists of dysgerminoma accompanied by endodermal sinus tumours, immature teratoma or choriocarcinoma. There are only few case reports of MGCTs with different combinations of malignant components. We present a very rare case of malignant MGCT in a 05 years old female child, who presented with difficulty in defecation for 6 months, swelling over sacral region for 2 months, along with bilateral inguinal swellings and difficulty in urination for 1 week. Swelling was firm, non-mobile & non-tender measuring 6.6x5 cm. On cytology it was diagnosed as malignant germ cell tumour, which was confirmed on histology as malignant MGCT (predominantly yolk sac tumour >90% and embryonal carcinoma (<10%)), metastasizing into bilateral inguinal lymph nodes.