Open AccessAnti-inflammatory activity of novel xanthone derivatives
Author(s) -
Darakhshan Parveen,
Amrita Parle,
R. C. SRIVASTAVA
Publication year - 2022
Publication title -
international journal of pharmaceutical chemistry and analysis
Language(s) - English
Resource type - Journals
eISSN - 2394-2797
pISSN - 2394-2789
DOI - 10.18231/j.ijpca.2021.034
Subject(s) - xanthone , docking (animal) , chemistry , nitro , stereochemistry , inflammation , combinatorial chemistry , pharmacology , medicine , organic chemistry , immunology , alkyl , nursing
As many diseases such as cancer, metabolic disorders, aging, and neurodegenerative diseases present themselves via inflammation,there is always a need to have better anti-inflammatory drugs. Xanthones, a unique scaffold with a 9H-Xanthen-9-one core structure possesses anti-inflammatory activity. This research work comprised of theoretically designing thirty 3-aminoalkoxy derivatives of xanthone, estimation of physicochemical properties and their Molecular Docking with COX-1 receptor. The best docking scores are possessed by LIG12, LIG23 and LIG30 which were halo substituted phenyl derivatives, LIG7 which had an anilino substitution and LIG27 which had ortho-nitro phenyl substituted derivative. The docking scores of LIG7, LIG12, LIG23, LIG27 and LIG30 were found to be -10.6, -10.7, -10.7, -10.8 and -10.5 kcal/mol.