Open AccessAnalytical tools in protein structure determination
Author(s) -
Kanishk Gupta,
Uttam Patle,
Uma D. Kabra,
Prashant Mishra,
Milind J. Umekar
Publication year - 2021
Publication title -
international journal of pharmaceutical chemistry and analysis
Language(s) - English
Resource type - Journals
eISSN - 2394-2797
pISSN - 2394-2789
DOI - 10.18231/j.ijpca.2021.021
Subject(s) - protein structure prediction , protein structure , computer science , protein structure database , sequence (biology) , computational biology , protein sequencing , protein function prediction , task (project management) , protein function , peptide sequence , biological system , biology , biochemistry , engineering , sequence database , systems engineering , gene
Three-dimensional protein structure prediction from amino acid sequence has been a thought-provoking task for decades, but it of pivotal importance as it provides a better understanding of its function. In recent years, the methods for prediction of protein structures have advanced considerably. Computational techniques and increase in protein sequence and structure databases have influence the laborious protein structure determination process. Still there is no single method which can predict all the protein structures. In this review, we describe the four stages of protein structure determination. We have also explored the currenttechniques used to uncover the protein structure and highpoint best suitable method for a given protein.