Open AccessGuillain-barré syndrome after purified vero cell rabies vaccination: An unusual case report
Author(s) -
Khichar Shubhakaran,
Amita Bhargava,
Sanjay Khoont
Publication year - 2021
Publication title -
ip indian journal of neurosciences/ip indian journal of neurosciences
Language(s) - English
Resource type - Journals
eISSN - 2581-916X
pISSN - 2581-8236
DOI - 10.18231/j.ijn.2021.029
Subject(s) - guillain barre syndrome , rabies , vaccination , immunology , virology , vero cell , medicine , rabies vaccine , immune system , molecular mimicry , polyradiculoneuropathy , acute motor axonal neuropathy , rabies virus , virus
Guillain-Barré syndrome (GBS) can be described as a collection of clinical syndromes that manifests as an acute inflammatory polyradiculoneuropathy with resultant weakness and diminished reflexes. Regarding pathophysiology of GBS, it is believed that autoimmunity- molecular mimicry plays a role in its pathogenesis. As the vaccines have an effect on the immune system it is reasonable that immunizations may be associated with subsequent GBS. Although rabies vaccines containing neural elements are very well known cause for GBS, no such positive correlation has been proven after newer formulations of rabies vaccine, derived from chick embryo cells. Here we report a case of GBS which developed after 5 weeks of anti-rabies vaccination (Purified Vero cell rabies vaccine) which was given after dog bite.